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To investigate the role of human equilibrative nucleoside transporter 1 (hENT1) in the pathogenesis of Parkinson’s disease (PD), we have generated hENT1 transgenic mice. We found that hENT1 expression in dopamine neurons under the control of the tyrosine hydroxylase (TH) promoter fully protects against 6-hydroxydopamine (6-OHDA)-induced nigrostriatal dopaminergic neuronal degeneration in hENT1 transgenic mice. Neuronal cell death induced by 6-OHDA was suppressed in hENT1 transgenic mice compared with that in wild-type mice, as evaluated by the number of TH-positive neurons, immunostaining of activated caspase-3, and the expression of Bcl-2 family member genes. These data suggest that hENT1 may be involved in the pathogenesis of PD and that hENT1 may be a novel therapeutic target for PD.It’s not often we get to travel to Chicago and interview some of the rising stars of the Italian dance scene. The performers on the poster of the film are all locals, and in New York, it might be hard to see these young artists on their own turf, but in the Windy City, they make their mark on the scene, and with good reason: Chicago is arguably the heart of American Northern Soul culture. Just as bootleg records became important for the British sounds of the 1960s, the popularity of the Italian scene in Chicago is proof of the allure of this dance music, and with its unique and diverse origins, it is especially relevant in the present.
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Use ShapeAssist to show approximate path information on a curve and prevent accidents.
The new AutoCAD User Interface, MDI and the ribbon bar are customizable. You can now set custom toolbars and the ribbon bar, including the mouse toolbars. (video: 2:30 min.)
Get a single, consolidated view of all your drawings. See exactly where you’ve been in your drawings and your customers’ drawings, so you can share project-wide feedback. (video: 1:20 min.)
Point Cloud Modeling:
Use point clouds to help optimize your models. Save time by finding complex models that are not modeled at all. (video: 2:45 min.)
Save time and get precise results with the new Speech Recognition interface. (video: 1:08 min.)
More Standards and Hints:
Use templates to speed up the process of creating, documenting and commenting on standards and specifications. (video: 2:15 min.)
The new MyProjects feature groups multiple drawings into a single drawing. And now, you can easily share your projects with others. (video: 1:22 min.)
Create 3D shell models, including shells for overhangs. (video: 2:36 min.)
Create dynamic blocks, including customizable dynamic blocks. (video: 1:38 min.)
Go to Dynamic Blocks:
Add dynamic blocks to your drawings without creating a script. (video: 1:10 min.)
A fresh new look for the Windows experience:
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Use the customizable Ribbon bar to:
Choose the number of workspaces you use. (video: 1:24 min.)
Show/hide the Dock Bar, top Nav Bar, Navigation Bar and Toolstrip Bar. (video: 1:05 min.)
New features for managing models:
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